![]() |
|
|
Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706
The effect of vitamin B6 depletion on the plasma concentration and urinary excretion of free amino acids before and following a 3.00 g L-methionine loading dose was studied in six male college students fed an experimental diet which supplied 150 g protein and 0.16 mg vitamin B6 daily. Vitamin B6 depletion caused a substantial increase in both the fasting and 2-hour postprandial plasma concentration of glycine, serine and threonine, a marked increase in the pre- and postmethionine urinary excretion of serine and threonine and a slight increase in the postmethionine urinary excretion of glycine. During vitamin B6 deprivation there also was a slight but significant decrease in the fasting plasma concentration of alanine, isoleucine, leucine and valine. Supplements of 2.00 mg pyridoxine daily to the subjects for 1 or 2 weeks caused the values to return to or approach predepletion levels.
Manuscript received 14 September 1970.
This article has been cited by other articles:
![]() |
H. F. Nijhout, J. F. Gregory, C. Fitzpatrick, E. Cho, K. Y. Lamers, C. M. Ulrich, and M. C. Reed A Mathematical Model Gives Insights into the Effects of Vitamin B-6 Deficiency on 1-Carbon and Glutathione Metabolism J. Nutr., April 1, 2009; 139(4): 784 - 791. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Lamers, J. Williamson, M. Ralat, E. P. Quinlivan, L. R. Gilbert, C. Keeling, R. D. Stevens, C. B. Newgard, P. M. Ueland, K. Meyer, et al. Moderate Dietary Vitamin B-6 Restriction Raises Plasma Glycine and Cystathionine Concentrations While Minimally Affecting the Rates of Glycine Turnover and Glycine Cleavage in Healthy Men and Women J. Nutr., March 1, 2009; 139(3): 452 - 460. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. R. Davis, E. P. Quinlivan, P. W. Stacpoole, and J. F. Gregory III Plasma Glutathione and Cystathionine Concentrations Are Elevated but Cysteine Flux Is Unchanged by Dietary Vitamin B-6 Restriction in Young Men and Women J. Nutr., February 1, 2006; 136(2): 373 - 378. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. M. Flugel-Link, M. R. Jones, and J. D. Kopple Red Cell and Plasma Amino Acid Concentrations in Renal Failure JPEN J Parenter Enteral Nutr, September 1, 1983; 7(5): 450 - 456. [Abstract] [PDF] |
||||