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Journal of Nutrition Vol. 101 No. 2 February 1971, pp. 185-191
Copyright © 1971 by American Society for Nutrition
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Effect of Vitamin B6 Depletion in Adult Man on the Plasma Concentration and the Urinary Excretion of Free Amino Acids1

Youngmee Kang Park and Hellen Linkswiler

Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706

The effect of vitamin B6 depletion on the plasma concentration and urinary excretion of free amino acids before and following a 3.00 g L-methionine loading dose was studied in six male college students fed an experimental diet which supplied 150 g protein and 0.16 mg vitamin B6 daily. Vitamin B6 depletion caused a substantial increase in both the fasting and 2-hour postprandial plasma concentration of glycine, serine and threonine, a marked increase in the pre- and postmethionine urinary excretion of serine and threonine and a slight increase in the postmethionine urinary excretion of glycine. During vitamin B6 deprivation there also was a slight but significant decrease in the fasting plasma concentration of alanine, isoleucine, leucine and valine. Supplements of 2.00 mg pyridoxine daily to the subjects for 1 or 2 weeks caused the values to return to or approach predepletion levels.

1 Published with approval of the Director of the Research Division of the College of Agricultural and Life Sciences.

Manuscript received 14 September 1970.


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