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Journal of Nutrition Vol. 101 No. 2 February 1971, pp. 161-168
Copyright © 1971 by American Society for Nutrition
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Phospholipid Metabolism in Vitamin A-deficient Rats1

R. F. Krause, Kathryn C. Beamer and Jane H. Plow

Department of Biochemistry, West Virginia University Medical Center, Morgantown, West Virginia 26506

The effect of vitamin A deficiency on the in vivo uptake of 32P-phosphoric acid, 14C-choline, 14C-oleic acid, 14C-palmitic acid and 14C-glycerol by phospholipids from subcellular fractions of rat liver and their mitochondrial membrane fractions was examined. Vitamin A deficiency resulted in an increased incorporation of 14C-choline, 14C-oleic and 14C-palmitic acids into phospholipids from various subcellular fractions. The majority of this increase was found in the phosphatidyl choline component of all subcellular fractions. The uptake of 14C-glycerol into the respective subcellular phospholipids from deficient and control animals was similar. In all instances the specific activity of the mitochondrial phospholipids was highest in the outer membrane fraction. The specific activity of the mitochondrial phospholipids labeled with 32P, 14C-choline, 14C-palmitic and 14C-oleic acids was highest in the outer membrane from deficient animals. The uptake of 14C-glycerol into the respective mitochondrial membrane fractions from control and deficient groups was approximately the same. No significant difference was noted in the fatty acid composition of total phospholipids from control and deficient groups.

1 The support of this work by US Public Health Service Grant AM-11597 is gratefully acknowledged.

Manuscript received 24 August 1970.




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