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Journal of Nutrition Vol. 101 No. 12 December 1971, pp. 1657-1661
Copyright © 1971 by American Society for Nutrition
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Hypertension in Young Rats Following Choline Deficiency in Maternal Diets1

C. C. Kratzing and J. J. Perry

Department of Physiology, University of Queensland, Brisbane, Australia, 4067

In order to determine whether maternal sources of choline were sufficient to protect the progeny from choline deficiency hypertension during maternal dietary deficiency, female rats were fed a choline-supplemented or -deficient diet either during gestation or lactation. Blood pressures of the young were determined after they were fed a choline-adequate diet for varying periods. When 35 to 58 days of age, the young from dams deficient in choline during gestation had blood pressures significantly higher than the young from choline-supplemented dams. When 84 to 111 days old, the young from choline-deficient and -supplemented dams showed no significant differences in blood pressure. Similar results were obtained for blood pressures of young from dams fed choline-deficient or -supplemented diets during lactation. Neither the choline-supplemented nor -deficient dams showed any significant changes in blood pressure during pregnancy or lactation. The results suggest that the development of the rat kidney is so protracted that addition of new tissue after weaning compensates for the hypertensive effects of kidney damage in choline deficiency.

KEY WORDS: • blood pressure • choline deficiency • lactation • pregnancy

1 Supported by a grant from the Life Insurance Medical Research Fund of Australia and New Zealand.

Manuscript received 28 June 1971.




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