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Distribution of ¹⁴C-Cyclamate in the Lactating Rat¹

Department of Nutrition, University of California, Davis, California 95616

Mammary excretion of cyclamate was studied in lactating rats. ¹⁴C-cyclamate was given to the rats by intravenous injection, and its movement was followed by scintillation counting and autoradiography. Simulation analysis was used in the interpretation of experimental results. Cyclamate was found to travel rapidly throughout the body, quickly reaching an initial equilibrium between the unionized fractions found in blood and milk. Kidney excretion led to an exponential decline of cyclamate from all samples other than milk, causing the concentration of cyclamate in milk to exceed that in the blood within approximately 1 hour. The very slow decline of cyclamate from the milk was shown to be primarily the result of the normal process of milk synthesis.

KEY WORDS: • cyclamate • lactation • autoradiography • simulation analysis

¹ Supported by International Sugar Research Foundation, Inc. Grant 254.

Manuscript received 22 June 1971.