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Journal of Nutrition Vol. 101 No. 12 December 1971, pp. 1631-1633
Copyright © 1971 by American Society for Nutrition
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Cellular Growth in Experimental Intrauterine Growth Retardation in Rats1

William Oh and Joyce A. Guy

Department of Pediatrics, Harbor General Hospital, UCLA School of Medicine, Torrance, California 90509

RNA, DNA and protein contents were measured in liver, brain and carcass of 22 fetuses with intrauterine growth retardation (IUGR) along with 28 controls. The IUGR was induced by ligation of uterine artery in one of the two uterine horns at 17 days of gestation. In IUGR, the liver and carcass weights were significantly reduced while the brain weights were comparable with the control fetuses. The total liver DNA and protein, as well as total carcass DNA, RNA and protein contents of IUGR fetuses were significantly reduced when compared with the controls. No differences in brain RNA, DNA and protein contents were observed between the two groups. These results suggest that uterine vascular insufficiency may induce fetal growth failure and that the retardation of organ growth affects the carcass and the liver. In both organs, the cell number and cell size growth were reduced. The brain growth is preferentially spared.

KEY WORDS: • cellular growth • fetal growth retardation • organ growth

1 Supported in part by Research Grant no. HD 4610-02 of the National Institutes of Health, Bethesda, Maryland.

Manuscript received 28 June 1971.


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[Abstract] [PDF]


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