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Undernutrition and Intestinal Dipeptide Hydrolase Activity in the Rat^1,2,

B. F. Stolinsky Laboratory, Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado 80220

The effects of undernutrition on intestinal mucosal dipeptide hydrolase, alkaline phosphatase, and disaccharidase activities were studied in infant and adult rats. Dipeptide hydrolase activities for glycylproline and valylproline were significantly reduced in undernourished animals at ages 7, 21, 42, and 68 days. The activity of leucylalanine dipeptide hydrolase was not significantly reduced in poorly nourished rats at ages 7, 21, 42, and 68 days, but was reduced at age 115 days. Alkaline phosphatase activity was reduced in undernourished animals at ages 21, 42, and 115 days.

² This work was supported by Grant 5 ROI NS 07537 from the National Institute of Neurological Diseases and Stroke.

³ Dr. Kumar's present address: Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

⁴ Dr. Chase is a recipient of a Career Research Development Award from the National Institute of Child Health and Human Development, K4-HD-38,839-03.

Manuscript received 4 March 1971.