Journal of Nutrition

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Journal of Nutrition Vol. 101 No. 10 October 1971, pp. 1327-1330
Copyright © 1971 by American Society for Nutrition
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Role of Vitamin E in the Regulation of Rabbit Liver Xanthine Dehydrogenase Activity1

George L. Catignani, Jr. and James S. Dinning2

Divisi1on of Nutrition, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

Vitamin E deficiency in rabbits results in a large increase in liver xanthine dehydrogenase activity, suggesting that vitamin E regulates the synthesis of this enzyme. It is postulated that increased liver xanthine dehydrogenase activity may be responsible for the anemia observed in vitamin E-deficient animals.


1 Supported by Public Health Service Training Grant 2T01 AM05441.

2 Associate Director, Biomedicai Sciences, The Rockefeller Foundation, New York. Visiting Professor, Department of Biochemistry, Vanderbilt University School of Medicine, February-October, 1970.

Manuscript received 25 November 1970.





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