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Journal of Nutrition Vol. 101 No. 1 January 1971, pp. 9-12
Copyright © 1971 by American Society for Nutrition
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Influence of Dietary Protein on the Activity of Microsomal Epoxidase in the Growing Rat1

Willard M. Weatherholtz2 and Ryland E. Webb

Department of Biochemistry and Nutrition, Virginia Polytechnic Institute, Blacksburg, Virginia 24061

Investigations of the influence of dietary protein level on the activity of hepatic microsomal epoxidase were undertaken to explain the effects of low protein diets on heptachlor toxicity. These studies showed that low protein diets resulted in lower levels of microsomal epoxidase when compared to controls fed adequate protein. The in vitro determination of epoxidase correlates closely with the observation that low protein diets cause a reduction in toxicity of heptachlor to weanling rats.

1 Supported in part by Public Health Service Grant no. ES 00257 from the National Institutes of Health and by Federal Hatch Funds.

2 From a dissertation submitted by the senior author in partial fulfillment of the requirements for the Ph.D. degree, Virginia Polytechnic Institute, Blacksburg, Virginia, 1969. Present address: Hazelton Laboratories, Inc., P. O. Box 30, Falls Church, Virginia 22046.

Manuscript received 8 June 1970.




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