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Elevation of Systolic Blood Pressure in Rats Fed Diets Containing Fish and Soybean Proteins^1,2,

Department of Food and Nutritional Sciences, University of Hawaii, Honolulu, Hawaii 96822

Significant elevations of systolic blood pressure were observed in weanling rats of a Wistar-derived strain fed a fresh diet of rice, skipjack tuna, soybean products and vegetables (simulated Japanese diet—4% NaCl by weight on a dry basis) for 3 months. No elevations of blood pressure occurred in similar animals fed a control diet or fresh diet from which fish or both fish and soybean products had been omitted. Significant elevation of blood pressure was also observed within 6 weeks in weanling male rats fed a semipurified dry diet (20% casein diet) altered to provide 12% by weight of defatted fish, 2.9% soybean protein and 5.1% casein, salted to provide 4% NaCl. Blood pressures remained normal in pair-fed weanling males fed salted diet (4% NaCl) containing 20% casein or 2.9% soybean protein plus 17.1% casein. It is concluded that fresh or defatted skipjack tuna was responsible for the hypertensive effects of the diets used.

² Presented in part at the Eighth International Congress of Nutrition, Prague, Czechoslovakia, August 25 to September 5, 1969. Based upon a thesis submitted by Montharop S. Chakkaphak in partial fulfillment of the requirements for the M.S. degree in Nutrition at the University of Hawaii.

³ Present address: Department of Food Science, Kasetsart University, Bangkhen, Bangkok, Thailand.

Manuscript received 2 January 1970.