QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kratzing, C. C. Articles by Ellway, C. P. Search for Related Content PubMed PubMed Citation Articles by Kratzing, C. C. Articles by Ellway, C. P.

Adrenergic Mechanisms in Choline-deficient Rats¹

Department of Physiology, University of Queensland, St. Lucia, Queensland 4067, Australia

The adrenergic control of hypertension in choline deficiency has been studied by the use of -methyl dopa (MD). The development of hypertension in male, weanling rats fed a choline-deficient diet was prevented by the MD without interference to the growth rate of the rats, by providing it at 50 mg/100 g food. At this level, MD did not have any effects on either liver weight or liver lipid content of the choline-deficient rats. MD had no measurable effects on choline-supplemented rats. The present results contrast with earlier work with ethyl trichloracetate which lowers hypertension and prevents excess liver lipid accumulation in choline deficiency. It is postulated that MD acts as a hypotensive agent through being an adrenergic blocking agent.

Manuscript received 29 December 1969.