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Journal of Nutrition Vol. 100 No. 6 June 1970, pp. 698-704
Copyright © 1970 by American Society for Nutrition
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Effect of Lithocholic Acid and Antibiotics on Tissue Bile Acids in the Rat1

P. P. Nair, Consolacion Garcia-Lilis and A. I. Mendeloff

Biochemistry Research Division, Department of Medicine, Sinai Hospital of Baltimore, Inc., Baltimore, Maryland 21215

The early changes in composition of major tissue bile acids in rats maintained on supplements of lithocholic acid (50 mg/day/rat) with and without antibiotics (Terramycin hydrochloride, 50 mg/day/rat and succinylsulfathiazole, 20 mg/day/rat) were studied. Lithocholic acid induced a specific depression of tissue cholic acid accompanied by an elevation in hepatic cholesterol levels. The concurrent administration of antibiotics prevented these changes only partially, suggesting that lithocholic acid, instead of its bacterial metabolites, controls cholic acid biogenesis probably by inhibiting the enzyme, 12{alpha}-hydroxylase. In addition, lithocholic acid could partially block the uptake of cholic acid in the small bowel, another site at which regulation of bile acid homeostasis could occur. These effects are considered primary attributes of lithocholic acid since antibiotics administered concurrently failed to restore normal metabolic profiles.

1 Supported by Grant AM-02131 and General Research Support Grant 5 SO-1FR-05478 from the National Institutes of Health, United States Public Health Service.

Manuscript received 27 October 1969.




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