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Chemical Pathology of Acute Amino Acid Deficiencies: Studies on Hepatic Enzymes in Rats Force-fed a Threonine-devoid Diet¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

Rats were force-fed a threonine-devoid or complete diet for 3 days and the activities of 10 hepatic enzymes were studied. The results indicated a significant increase in glucose-6-phosphate dehydrogenase activity and significant decreases in activities of phosphorylase, urocanase and the hydroxylating enzyme which leads to demethylation of Pyramidon in animals fed the threonine-devoid diet in comparison with those fed the complete diet. Other enzymes, glycogen synthetase, malic enzyme, threonine dehydrase, arginase, histidase and acid phosphatase, showed no significant differences between the experimental and control animals.

² Present address: Punjab Agricultural University, Ludhiana-I, Punjab, India.

Manuscript received 12 January 1970.