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Food Intake Depression and Other Metabolic Effects of Tannic Acid in the Rat^{1, 2,}

Department of Nutritional Sciences, University of California, Berkeley, California 94720

The food intake depression and subsequent decrease in growth of rats fed tannic acid was determined at the 4, 5 and 8% level. Pair feeding and supplementation with additional casein, choline or methionine were used to investigate the mechanism of growth depression. Depression of growth occurred due to factors in addition to those which reduce feed intake. No anemia or fatty livers were observed with 5% tannic acid in the diet. Supplementation with choline or methionine had no effect but supplementation with casein improved growth. The toxicity of the tannin decreased with increase in age and weight of rat. Older and heavier rats were able to recover and adjust to tannin in the diet.

² Supported in part by Public Health Service Research Grant no. UI-EF-00080 from the National Center for Urban and Industrial Health.

³ Present address: Heller Institute of Medical Research, Department of Medicine, Tel-Hashomer Hospital, Tel-Aviv University, Tel Aviv, Israel.

Manuscript received 1 July 1969.