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Pyridoxine Effects on Cystathionine Synthase in Rat Liver¹

Veterans Administration Hospital and Department of Medicine, George Washington University School of Medicine, Washington, D. C. 20422

The livers of rats fed a pyridoxine-deficient diet had reduced specific activities of methionine-activating enzyme, cystathionine synthase, cystathionase, and betaine-homocysteine methyltransferase. When we added pyridoxal phosphate in vitro, the activities of cystathionine synthase and cystathionase increased while the levels of the other two enzymes remained unchanged. Cystathionase is a pyridoxal-dependent enzyme. We suggest that cystathionine synthase also requires this cofactor.

Manuscript received 5 December 1969.

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