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Effects of Pyrithiamin Injection into the Brain of Rats

Institute of Human Physiology, University of Pavia, Pavia, Italy

Simple dietary thiamin deficiency (8 days) caused a greater decrease (68%) in free thiamin content in the brain than in thiamin phosphates (27%), without bringing about any neurological symptoms of athiaminosis. Injection of 0.03, 0.15 or 0.60 µmole of pyrithiamin into the brains of rats fed a thiamin-deficient diet caused an increase in free thiamin cerebral content in proportion to the dose injected. At the same time, the cerebral content of thiamin phosphates decreased. The oral administration of thiamin for 8 days (0.15 µmole daily) tended to cancel this modification.