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Journal of Nutrition Vol. 100 No. 3 March 1970, pp. 375-379
Copyright © 1970 by American Society for Nutrition
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Triglyceride Transport in Protein-depleted Rats1,2,

Hernando Flores, Walter Sierralta3 and Fernando Monckeberg

Laboratorio de Investigaciones Pediatricas, Facultad de Medicina, and Catedra de Nutricion, Facultad de Quimica y Farmacia, Universidad de Chile, Casilla 5370, Santiago 3, Chile

The hypothesis that fatty liver in protein malnutrition is produced mainly by a deficit in the availability of the protein moiety of low density lipoproteins was investigated in rats. The animals were made protein-depleted by feeding a protein-free diet. They developed fatty livers as well as several other symptoms characteristic of infantile protein malnutrition. The injection of a plasma protein fraction containing the apoprotein of low density lipoproteins as compared to albumin-injected controls produced an increase of 80% in the fasting plasma triglyceride levels and a significantly higher incorporation of 131I-oleic acid into triglycerides of d < 1.020 plasma lipoprotein. These effects were not observed in normal, well-nourished animals. The results of these experiments strongly suggest that in protein malnutrition the protein moiety of low density lipoproteins is the limiting factor for their synthesis. The impaired rate of synthesis of the lipoprotein would cause triglycerides to accumulate in the liver.

1 Supported by National Institutes of Health Grant 9-322-HDO 3741-08 and by funds for project (69-54) 25014262 from Comision de Investigacion Cientifica, Facultad de Medicina, Universidad de Chile.

2 Presented in part at the first meeting of the Sociedad Latinoamericana de Nutricion, Caracas, Venezuela, 1968, and in the degree thesis of one of us (W.S.), Universidad de Chile, 1968.

3 Present address: Departamento de Ciencias Fisiologicas, Facultad de Ciencias Pecuarias y Medicina Veterinaria, Universidad de Chile.

Manuscript received 4 September 1969.




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