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Journal of Nutrition Vol. 100 No. 3 March 1970, pp. 315-324
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Effects of Nutritional Status on Rat Brain Maturation as Measured by Lipid Composition1

R. L. Geison and Harry A. Waisman

Joseph P. Kennedy Jr. Laboratory, Department of Pediatrics, University of Wisconsin Medical Center, Madison, Wisconsin 53706

Alteration of the rate of growth of suckling rats produces changes in the concentrations of several brain lipid components (galactolipid, cholesterol, plasmalogens) and chloroform-methanol extractable protein (proteolipid protein). The results suggest that the rates of lipid accumulation in suckling rats are related to the body and brain growth. A reduced rate of growth causes a delay in the accumulation of lipids with the concentrations of the various lipids being maintained proportional to younger, faster growing rats. After a recovery period, depressions in levels of lipid components may exist, depending on the final body weights attained. Greater depressions in the concentration of myelin-related lipids are found in rats of smaller body weight suggesting that a deficit in myelin still exists and that the accumulation of lipids is related to the previous overall rate of maturation and development.

1 Supported by U. S. Public Health Service Grants HD-00341 and HD-00131 from the National Institute of Child Health and Human Development, and a grant from the Brittingham Trust fund. A preliminary report of part of this work has been published: Geison, R. L. 1967 Federation Proc. 26: 510 (abstract).

Manuscript received 2 June 1969.




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