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Journal of Nutrition Vol. 100 No. 2 February 1970, pp. 228-234
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Effect of Vitamin D Deficiency and the Role of Citrate in Kidney Calcification of Magnesium-deficient Rats1

Mary Jacob2 and R. M. Forbes

Nutritional Biochemistry Division, Animal Science Department, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

Weanling male albino rats were used in studies designed to investigate the relationship of vitamin D status and other parameters affecting citrate and mineral metabolism on renal calcification in magnesium deficiency. In experiment 1 the basal diet contained 0.5% calcium and 0.5% phosphorus, 90 ppm of magnesium and no known source of vitamin D. Magnesium (600 ppm), vitamin D (1.25 IU per gram) and galactose (15%) were included in diets to form a 23 factorial design. In experiment 2 the effect of L-thyroxine on citrate excretion was studied in magnesium-deficient and normal animals. Kidney calcification was produced only in the presence of vitamin D and was prevented by thyroxine treatment, although these treatments each increased urinary citrate excretion. Serum citrate levels were not influenced by magnesium but were increased by vitamin D and by galactose. Thus urine citrate was not correlated with either serum citrate or kidney calcification.

1 Includes portions of a thesis submitted by Mary Jacob to the Graduate College, University of Illinois, Urbana-Champaign, in partial fulfillment of the requirements for the Doctoral degree in Nutritional Sciences.

2 Present address: School of Public Health, University of California, Los Angeles.

Manuscript received 5 September 1969.




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