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Biochemical and Histological Study of Guinea Pig Fetal and Uterine Tissue in Ascorbic Acid Deficiency1

Jerry M. Rivers, Lennart Krook and Sister Auréa Cormier2

Department of Human Nutrition and Food, College of Human Ecology, Cornell University, Ithaca, New York 14850

Fetal and uterine tissues from ascorbic acid-deficient and control guinea pigs were assayed for ascorbic acid, proline, and hydroxyproline and examined histologically for changes in connective tissue metabolism. Results of the biochemical assays showed that collagen synthesis was impaired in both fetal and uterine tissue from deficient animals. Histologically, the deficient fetal and uterine tissues showed abnormalities in the mucopolysaccharides, collagen and elastin components. These results were obtained on pregnant animals that showed no outward signs of as corbic acid deficiency.

1 Supported by Public Health Service Research Grant no. AM 08249 from the National Institute of Arthritis and Metabolic Diseases. The histopathological part of this study was undertaken in the facilities provided by National Institutes of Health Training Grant no. GM 213. The grants are gratefully acknowledged.

2 Part of the data in this paper was presented in a thesis submitted to the Graduate School of Cornell University in partial fulfillment of the requirement for the M.S. degree.

Manuscript received 24 April 1969.




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