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Metabolism of Thiamin in the Hyperthyroid Rat

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

The effect of physiological doses of thyroxine on the depletion of tissue thiamin and on the fate of 2-¹⁴C-thiazole thiamin in rats fed a thiamin-deficient diet was investigated. Thyroxine increased the rate of depletion of liver thiamin, but did not affect muscle thiamin or erythrocyte transketolase activity. The rate of excretion of labeled thiamin metabolites in rat urine and feces was independent of prior or subsequent thiamin status and was unaltered by thyroxine. In contrast, thyroxine increased the elimination rate of respiratory ¹⁴CO₂ originating from labeled thiamin. On the basis of these findings, it is postulated that multiple tissue pools of thiamin are reflected by the urinary, fecal, and respiratory routes of elimination of thiamin metabolites and by the different rates of turnover of liver and muscle thiamin.

² Reprint requests should be sent to S. R. Tannenbaum, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

Manuscript received 6 May 1969.