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Journal of Nutrition Vol. 100 No. 12 December 1970, pp. 1431-1435
Copyright © 1970 by American Society for Nutrition
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Dietary Orotic Acid and Lipogenesis in the Rat1

G. J. Klain, F. J. Sullivan and A. W. Meikle

Physiology Division, U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado 80240

Compared to the controls, activities of hepatic enzymes involved in fatty acid synthesis were decreased in rats ingesting orotic acid for 6 days or longer. In contrast, activities of these enzymes were markedly enhanced in adipose tissue. Fatty acid synthesis and 14CO2 production from glucose-U-14C were depressed in liver and stimulated in white or brown adipose tissue. The data obtained in an in vivo study follow a pattern similar to those observed with in vitro preparations. The results suggest that orotic acid increases fatty acid turnover in adipose tissue.

1 In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institutes of Laboratory Animal Resources, National Academy of Sciences-National Research Council.

Manuscript received 22 June 1970.




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