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⁶⁵Zn Absorption Rate Following Single Duodenal Dosing in Calves Fed Zinc-deficient or Control Diets^1,2,3,

Dairy Science Department and School of Veterinary Medicine, University of Georgia, Athens, Georgia 30601

Effects of dietary zinc level on ⁶⁵Zn absorption and its movement in the intestinal tract were studied in calves fed zinc-deficient (5 ppm Zn) and control (37 ppm Zn) purified diets for 2 weeks. The calves were killed at 1, 4, 8, and 24 hours after dosing via duodenal catheter. Absorption, defined as ⁶⁵Zn unrecovered in intestinal contents and feces, was very rapid during the first hour for both dietary treatments. After 1 hour, absorption progressively diminished with little absorption after 8 hours. The deficient diet substantially increased ⁶⁵Zn absorption. Blood ⁶⁵Zn levels increased sharply during the first 0.5 hour and tended to decline from 1 to 24 hours. Liver and kidney ⁶⁵Zn values reflected absorption and in conjunction with blood data indicated that ⁶⁵Zn, following removal from the intestinal contents, was rapidly transferred to the blood and transported to body tissues. Passage of ⁶⁵Zn down the small intestine was rapid and substantially faster for control than for deficient-fed calves. In controls at 4 hours, most of the unabsorbed ⁶⁵Zn was beyond the small intestine. Relating intestinal movement data to ⁶⁵Zn absorption suggested that little absorption occured in the cecum or beyond.

² From a dissertation by the senior author in partial fulfillment of the requirements for the Ph.D. degree.

³ Appreciation is extended to the Kraft Foods Co., Garland, Texas for dried whole whey; to the Chas. Pfizer Co., Terre Haute, Ind. for antibiotics and vitamins; to Hoffmann-LaRoche, Inc., Nutley, N. J. for the biotin; to the Commercial Solvents Co., New York, for choline; to Merck and Co., Rahway, N. J. for pyridoxine and vitamin B₁₂; to Distillation Products Industries, Rochester, N. Y. for d-a-tocopheryl acetate; to American Cyanamid Co., Princeton, N. J. for folic acid; to Abbott Laboratories, North Chicago, Ill. for menadione; to Basic, Inc., Cleveland, Ohio for magnesium oxide; to the Allied Chemical Co., Atlanta, Ga. for urea, and to the Gold Kist Feed Department of Cotton Producers, Atlanta, Ga. for feed used prior to the experiments.

Manuscript received 10 April 1970.