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Zinc Deficiency and Urinary Excretion of Taurine-³⁵S and Inorganic Sulfate-³⁵S Following Cystine-³⁵S Injection in Rats

Biochemistry Research Laboratory, Veterans Administration Hospital, and the Department of Biochemistry, The Johns Hopkins University, Baltimore, Maryland 21218

The effect of zinc deficiency on cystine oxidation was studied by comparing the amounts of labeled ³⁵S found in urinary inorganic sulfate and taurine following injection of cystine-³⁵S into zinc-deficient and zinc-supplemented rats. The results show that rats receiving a diet low in zinc for 1 week excreted significantly more ³⁵S than control animals. At the end of 3 weeks the recovery of injected ³⁵S in the urine of zinc-deficient rats was three to four times greater than that of zinc-supplemented controls. This increase was due to zinc deficiency per se rather than to a reduction of food consumption, and disappeared upon zinc repletion. It was further demonstrated that the bulk of the excess sulfur found in the urine of rats following zinc deficiency was due to increased amount of both inorganic sulfate and taurine. Zinc-deficient rats also significantly increased the urinary excretion of ³⁵S and ³⁵SO₄^2- after injection of ³⁵S-labeled methionine, thiamin, thiourea and inorganic sulfate. Liver ATP sulfurylase was not affected by zinc deficiency indicating that zinc-deficient rats were capable of converting inorganic sulfate to its active form.

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