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Effect of Diets of Different Protein Values on the Development of Osteolathyrism in Rats Given ß-Aminopropionitrile

Food Science and Nutrition Research Department, National Research Centre, Dokki, Cairo, UAR

Young hooded rats were fed ad libitum diets containing net percentages of dietary protein calories (NDpCal%) of 10.1, 6.2, 4.6, 3.7, or 2.1%; a diet of 4.6 NDpCal% with intake restricted to 75% of ad libitum fed rats; or a nonprotein diet. For animals exposed to osteolathyrogen, ß-aminopropionitrile fumarate (BAPN) was mixed with the diets to supply a daily intake of 0.8 mg/g body weight. Osteolathyrism developed first in rats maintained on a diet of 4.6 NDpCal%; diets with protein value above or below 4.6 progressively reduced the time of appearance of the exostoses. Rats fed a diet with NDpCal 4.6% but with intake restricted to 75% of the ad libitum intake, and those fed a nonprotein diet, died after 18 days without developing radiological signs of intoxication. The time of appearance (as judged radiologically) of the lesions produced by BAPN in animals administered L-thyroxine was slightly delayed in those fed diets with NDpCal% of 4.6, 6.2 and 10.1; no evidence of exostoses was observed in animals fed diets of lower protein value.