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Journal of Nutrition Vol. 100 No. 1 January 1970, pp. 101-109
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Effects of Vitamin E and Essential Fatty Acid Deficiencies on the Intestinal Transport of L-Valine and {alpha}-Methyl-D-Glucoside in the Rat1

Riazul H. Imami2, Sheldon Reiser and Philip A. Christiansen

Gastrointestinal Research Laboratory and Departments of Medicine and Biochemistry, Indiana University School of Medicine and Veterans Administration Hospital, Indianapolis, Indiana

To correlate a possible functional role of lipid-soluble factors in membranes with a requirement for the intestinal transport of amino acids (valine) and sugars ({alpha}-methyl-D-glucoside), using the in vitro everted sac technique, vitamin E and essential fatty acid deficiencies were nutritionally induced in rats. The deficiencies were confirmed by growth, physical appearance, and by photometric and chromatographic analyses of tissue. Deficiency of vitamin E decreased all the transport parameters of the amino acid while having no effect on the transport of the sugar. An essential fatty acid deficiency decreased both amino acid and sugar transport by decreasing the rate of transfer from the tissue uptake site to the serosal medium. These results indicate that vitamin E may be functional at the tissue uptake level of amino acid transport while the essential fatty acids may be required for an optimum energy supply.

1 Supported in part by Public Health Service Grants AMO5932 and AM5223 from the National Institutes of Health, and by a grant from the Allen County Cancer Society.

2 Present address: Methodist Hospital, Peoria, Ill.

Manuscript received 22 July 1969.




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