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Department of Internal Medicine, Yale University, New Haven
Calcium, phosphorus and nitrogen balances in three subjects before and during administration of dinitrophenol are reported. An increase of 37 per cent in the basal metabolic rate is accompanied by no significant change in the excretion of these elements. The excretion of ammonia and the titratable acidity minus CO2 in the urine of one subject was unaltered by the increase in oxidative metabolism due to dinitrophenol. The studies offer further evidence that increased metabolism of the body as a whole is not necessarily shared by the skeleton, at least in so far as changes in the intrinsic metabolism of bones are measurable by alterations in the total exchanges of the bone salts.